Invention Grant
- Patent Title: Inhibitors of the interaction between MDM2 and P53
- Patent Title (中): MDM2与P53相互作用的抑制剂
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Application No.: US12678961Application Date: 2008-09-18
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Publication No.: US09573933B2Publication Date: 2017-02-21
- Inventor: Virginie Sophie Poncelet , Sophie Coupa , Pierre-Henri Storck , Bruno Schoentjes
- Applicant: Virginie Sophie Poncelet , Sophie Coupa , Pierre-Henri Storck , Bruno Schoentjes
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Priority: EP07116889 20070921
- International Application: PCT/EP2008/062433 WO 20080918
- International Announcement: WO2009/037308 WO 20090326
- Main IPC: C07C59/13
- IPC: C07C59/13 ; C07D311/04 ; A61K31/352 ; C07D491/052 ; A61K31/4741 ; C07D405/10 ; A61K31/4184 ; A61K31/192 ; C07D405/04 ; A61K31/4709 ; C07D409/10 ; A61K31/381 ; A61K45/06 ; C07D401/12 ; C07D487/04

Abstract:
The present invention provides compounds of formula (I), their use as an inhibitor of a p53-MDM2 interaction as well as pharmaceutical compositions comprising said compounds: wherein n, m, p, s, t, R1, R2, R3, R4, R5, R6, R7, R20, X, Y, Q and Z have defined meanings.
Public/Granted literature
- US20100240637A1 Inhibitors of the Interaction Between MDM2 and P53 Public/Granted day:2010-09-23
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