Invention Grant
- Patent Title: Quinoline derivative
- Patent Title (中): 喹啉衍生物
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Application No.: US14906993Application Date: 2014-07-23
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Publication No.: US09573935B2Publication Date: 2017-02-21
- Inventor: Takayuki Inukai , Jun Takeuchi , Tomoko Yasuhiro
- Applicant: ONO PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Osaka
- Assignee: ONO PHARMACEUTICAL CO., LTD.
- Current Assignee: ONO PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Osaka
- Agency: Sughrue Mion, PLLC
- Priority: JP2013-153350 20130724
- International Application: PCT/JP2014/069419 WO 20140723
- International Announcement: WO2015/012298 WO 20150129
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D401/12 ; C07D215/54

Abstract:
A compound represented by general formula (I) has a strong Axl inhibitory activity by introducing a distinctive bicyclic structure in which a saturated carbon ring is fused to a pyridone ring, and can be a therapeutic agent for Axl-related diseases, for example, cancer such as acute myeloid leukemia, melanoma, breast cancer, pancreatic cancer, and glioma, kidney diseases, immune system diseases, and circulatory system diseases.
Public/Granted literature
- US20160168121A1 QUINOLINE DERIVATIVE Public/Granted day:2016-06-16
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