Invention Grant
- Patent Title: Process for the preparation of Dolutegravir
- Patent Title (中): 制备Dolutegravir的方法
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Application No.: US14888702Application Date: 2014-02-07
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Publication No.: US09573965B2Publication Date: 2017-02-21
- Inventor: Shankar Reddy Budidet , Nageshwar Dussa , Gowrisankar Rao Kaki , Srinivasa Rao Yatcherla , Jagan Mohan Reddy Sanapureddy , Subba Reddy Danda , Srinivasachary Katuroju , Sivakumaran Meenakshisunderam
- Applicant: Aurobindo Pharma Ltd
- Applicant Address: IN Hyderabad
- Assignee: Aurobindo Pharma Ltd
- Current Assignee: Aurobindo Pharma Ltd
- Current Assignee Address: IN Hyderabad
- Agent Jay R Akhave
- Priority: IN725/CHE/2013 20130219; IN1361/CHE/2013 20130327
- International Application: PCT/IB2014/000149 WO 20140207
- International Announcement: WO2014/128545 WO 20140828
- Main IPC: C07D498/14
- IPC: C07D498/14 ; C07C213/08 ; C07C215/08 ; C07C213/02 ; C07C213/10 ; C07C59/255
Abstract:
The present invention provides (R)-3-Amino-1-butanol (D)-tartarate (IIb); process for its preparation and its conversion to Dolutegravir. The present invention also provides an improved process for the preparation of Dolutegravir (I) or pharmaceutically acceptable salts wherein compound (XVI) is reacted with an optically active acid addition salt of (R)-3-amino-1-butanol (IIa).
Public/Granted literature
- US20160108058A1 An improved process for the preparation of Dolutegravir Public/Granted day:2016-04-21
Information query
