Invention Grant
US09573974B2 Multi-leu peptides and analogues thereof as selective PACE4 inhibitors and effective antiproliferative agents
有权
多肽和其类似物作为选择性PACE4抑制剂和有效的抗增殖剂
- Patent Title: Multi-leu peptides and analogues thereof as selective PACE4 inhibitors and effective antiproliferative agents
- Patent Title (中): 多肽和其类似物作为选择性PACE4抑制剂和有效的抗增殖剂
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Application No.: US14149857Application Date: 2014-01-08
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Publication No.: US09573974B2Publication Date: 2017-02-21
- Inventor: Robert Day , Martin Fugére , Witold A. Neugebauer
- Applicant: LA SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA-SCIENCES SANTE ET HUMAINES S.E.C.
- Applicant Address: CA Sherbrooke
- Assignee: LA SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA-SCIENCES SANTE ET HUMAINES S.E.C.
- Current Assignee: LA SOCIETE DE COMMERCIALISATION DES PRODUITS DE LA RECHERCHE APPLIQUEE SOCPRA-SCIENCES SANTE ET HUMAINES S.E.C.
- Current Assignee Address: CA Sherbrooke
- Agency: Norton Rose Canada LLP
- Main IPC: A61K38/00
- IPC: A61K38/00 ; C07K7/06 ; C07K5/11 ; C07K14/81 ; C12Q1/37
Abstract:
Disclosed herein are PACE4 inhibitors, compositions comprising PACE4 inhibitors and their uses thereof for lowering PACE4 activity, reducing cell proliferation, reducing tumor growth, reducing metastasis formation, preventing and/or treating cancer. Also provided are methods for lowering PACE4 activity, reducing the proliferation of a cell, reducing tumor growth and/or treating and preventing cancer. Methods for screening PACE4 inhibitors and cell proliferation inhibitors are further provided.
Public/Granted literature
Information query
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