Invention Grant
US09573983B2 Compositions including I-domain antigen conjugate compounds and methods for treatment of autoimmune disorders
有权
包含I结构域抗原共轭化合物的组合物和治疗自身免疫性疾病的方法
- Patent Title: Compositions including I-domain antigen conjugate compounds and methods for treatment of autoimmune disorders
- Patent Title (中): 包含I结构域抗原共轭化合物的组合物和治疗自身免疫性疾病的方法
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Application No.: US13733991Application Date: 2013-01-04
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Publication No.: US09573983B2Publication Date: 2017-02-21
- Inventor: Teruna J. Siahaan , Prakash Manikwar , Paul Kipkemboi Kiptoo , Ahmed Badawi , Barlas Buyuktimkin , John M. Stewart
- Applicant: University of Kansas
- Applicant Address: US KS Lawrence
- Assignee: UNIVERSITY OF KANSAS
- Current Assignee: UNIVERSITY OF KANSAS
- Current Assignee Address: US KS Lawrence
- Agency: Thomas Horstemeyer, LLP
- Main IPC: C07K14/47
- IPC: C07K14/47 ; C07K14/705
Abstract:
The present disclosure provides IDAC compounds capable of presenting two or more signal 1 moieties to a host immune system and methods of using the IDAC compounds to treat or prevent autoimmune disorders in a subject. The present disclosure provides compounds including a modified I-domain peptide having two or more modified lysine residues and two or more signal 1 moieities conjugated to the modified lysine residues of the I-domain peptide and methods of using an making the compounds.
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