Invention Grant
- Patent Title: Antibodies against human FZD5 and FZD8
- Patent Title (中): 针对人FZD5和FZD8的抗体
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Application No.: US14605560Application Date: 2015-01-26
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Publication No.: US09573998B2Publication Date: 2017-02-21
- Inventor: Austin L. Gurney , Aaron Ken Sato , Fumiko Takada Axelrod , Timothy Charles Hoey , Sanjeev H. Satyal , Satyajit Sujit Kumar Mitra
- Applicant: OncoMed Pharmaceuticals, Inc.
- Applicant Address: US CA Redwood City
- Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee: OncoMed Pharmaceuticals, Inc.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; A61K45/06 ; A61K39/00
Abstract:
Novel anti-cancer agents, including, but not limited to, antibodies, that bind to human frizzled receptors are provided. Novel epitopes within the human frizzled receptors which are suitable as targets for anti-cancer agents are also identified. Methods of using the agents or antibodies, such as methods of using the agents or antibodies to inhibit Wnt signaling and/or inhibit tumor growth are further provided.
Public/Granted literature
- US20150232554A1 FRIZZLED-BINDING AGENTS AND USES THEREOF Public/Granted day:2015-08-20
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