Invention Grant
- Patent Title: Polynucleotides encoding VEGF/DLL4 binding agents
- Patent Title (中): 编码VEGF / DLL4结合剂的多核苷酸
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Application No.: US15163301Application Date: 2016-05-24
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Publication No.: US09574009B2Publication Date: 2017-02-21
- Inventor: Austin L. Gurney , Aaron Ken Sato , Christopher John Bond
- Applicant: OncoMed Pharmaceuticals, Inc.
- Applicant Address: US CA Redwood City
- Assignee: ONCOMED PHARMACEUTICALS, INC.
- Current Assignee: ONCOMED PHARMACEUTICALS, INC.
- Current Assignee Address: US CA Redwood City
- Agency: Sterne, Kessler, Goldstein and Fox P.L.L.C.
- Main IPC: C12N5/10
- IPC: C12N5/10 ; C07K16/24 ; C07K16/30 ; C07K16/22 ; A61K39/00
Abstract:
The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer.
Public/Granted literature
- US20160362499A1 Polynucleotides Encoding VEGF/DLL4 Binding Agents Public/Granted day:2016-12-15
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