Invention Grant
- Patent Title: Lysosomal protein targeting sequence and therapeutic applications of same
- Patent Title (中): 溶酶体蛋白靶向序列及其治疗应用
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Application No.: US14494065Application Date: 2014-09-23
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Publication No.: US09574184B2Publication Date: 2017-02-21
- Inventor: Gregory A. Grabowski , Benjamin Liou
- Applicant: Children's Hospital Medical Center
- Applicant Address: US OH Cincinnati
- Assignee: Children's Hospital Medical Center
- Current Assignee: Children's Hospital Medical Center
- Current Assignee Address: US OH Cincinnati
- Agency: Frost Brown Todd LLC
- Main IPC: C12N9/24
- IPC: C12N9/24 ; A61K38/00
Abstract:
The present disclosure relates to methods of treating diseases states such as lysosomal storage diseases and/or neurodegenerative diseases. Also disclosed are one or more compositions that may be useful for one or more of the disclosed methods, including compositions that may comprise acid β-glucosidase (GCase) protein comprising one or more mutations, peptides of acid β-glucosidase, and DNA vectors and cell lines related to acid β-glucosidase peptides or proteins.
Public/Granted literature
- US20160237414A1 LYSOSOMAL PROTEIN TARGETING SEQUENCE AND THERAPEUTIC APPLICATIONS OF SAME Public/Granted day:2016-08-18
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