Invention Grant
- Patent Title: Selective inhibition of polyglutamine protein expression
- Patent Title (中): 选择性抑制聚谷氨酰胺蛋白表达
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Application No.: US13575842Application Date: 2011-02-03
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Publication No.: US09574191B2Publication Date: 2017-02-21
- Inventor: David R. Corey , Jiaxin Hu , Dinah W. Y. Sah
- Applicant: David R. Corey , Jiaxin Hu , Dinah W. Y. Sah
- Applicant Address: US TX Austin
- Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TX Austin
- Agency: Norton Rose Fulbright US LLP
- International Application: PCT/US2011/023615 WO 20110203
- International Announcement: WO2011/097388 WO 20110811
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113 ; A61K31/713 ; A61K38/17
Abstract:
The present invention relates to the selective inhibition of protein expression of CAG repeat-related disease proteins such as Huntingtin Disease Protein and Ataxin-3 using double-stranded RNAs and nucleic acid analogs. Chemically-modified RNAs having at least one mismatch as compared to the target CAG repeat sequence are specifically contemplated.
Public/Granted literature
- US20130172399A1 SELECTIVE INHIBITION OF POLYGLUTAMINE PROTEIN EXPRESSION Public/Granted day:2013-07-04
Information query
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