A turbocharger control system for an internal combustion engine having first and second turbochargers connected in series includes first and second pressure sensors, and a controller. The first and second pressure sensors are disposed in an air intake of the engine, and are configured to sense boost pressure of the first and second turbochargers, respectively. The controller is configured to receive pressure signals from the first and second pressure sensors, and to control operation of at least one of the first and second turbochargers to maintain a desired boost pressure ratio.