A system, methods, and apparatus for virtual device timeout by memory offlining. A hypervisor receives a message from a source virtual machine to be transmitted to a destination machine and reserves a block of memory associated with the message. The message received from the source virtual machine is transmitted to the destination machine. The hypervisor then determines whether to reclaim the block of memory. If reclaiming the block of memory, the hypervisor offlines the block of memory by offlining one or more pages corresponding to the block of memory and/or offlining all memory corresponding to the source virtual machine. The hypervisor then indicates to the source virtual machine that the block of memory is accessible.