A method for planning an infusion of a medical substance into a target region acquires non-patient-specific anatomical data from an atlas in the form of target region geometry information describing target and off-target regions for which an infusion of the medical substance is intended and regions to be avoided, respectively. Target coverage information is derived describing a minimum dose of the medical substance to be infused into the target region and describing a maximum dose of the medical substance to be applied to the off-target region. Relationship information describes a relationship between a physical parameter of an infusion setup and a selected spatial distribution of the medical substance. Infusion setup information for the infusion is determined that describes a planned infusion setup and is based on the relationship information and information related to the target and off-target regions.