A secure device is used for securing a printed circuit board assembly. The secure device includes a fixed base and a plurality of removable securing member. The fixed base includes a base body, a plurality of locking structures and fixed structures. The fixed structure has a key-shape hole. Each of the removable securing members respectively includes a post, an interference portion and a lock portion. When the printed circuit board assembly is operated to be secured by the removable securing members, a first side of the printed circuit board assembly needs to be locked by the locking structure firstly; the interference portion of each removable securing member needs to be inserted into the key-shape hole, and interfered with the key-shape hole after the respective of the removable securing members is turned along a rotation direction, thereby to make the printed circuit board assembly secured by the removable securing members.