A backpack with multiple connected airbags includes a backpack body, a first airbag unit, and at least an air inlet. The backpack body has a set of straps. The first airbag unit includes a plurality of first airbags and is connected to the rear side of the backpack body. A groove and an air channel are formed between each two adjacent first airbags. The air channels allow the air in the first airbags to flow between the first airbags. The first airbags are so arranged that each first airbag in the peripheral region of the first airbag unit occupies a larger area on the rear side of the backpack body than any first airbag in the central region. The air inlet is in communication with at least one first airbag. The backpack can lie compliantly against the user's back to provide enhanced comfort and stability while protecting the user's spine.