Invention Grant
US09579367B2 C-terminally tethered amino acids and their fibrinolytic therapeutic uses
有权
C-末端系链氨基酸及其纤维蛋白溶解治疗用途
- Patent Title: C-terminally tethered amino acids and their fibrinolytic therapeutic uses
- Patent Title (中): C-末端系链氨基酸及其纤维蛋白溶解治疗用途
-
Application No.: US14303101Application Date: 2014-06-12
-
Publication No.: US09579367B2Publication Date: 2017-02-28
- Inventor: Ed Pryzdial
- Applicant: CANADIAN BLOOD SERVICES
- Applicant Address: CA Ottawa
- Assignee: Canadian Blood Services
- Current Assignee: Canadian Blood Services
- Current Assignee Address: CA Ottawa
- Agency: Norton Rose Fulbright US LLP
- Main IPC: A61K38/36
- IPC: A61K38/36 ; A61K38/48 ; C07D207/452 ; C12N9/74 ; C12N9/48 ; A61K38/49 ; C12N9/64
Abstract:
The present disclosure provides a C-terminal tethered amino acid for modulating the thrombolytic, fibrinolytic and/or anticoagulant properties of a coagulation protein. The present disclosure also provides a coagulation protein having a catalytic site modified, either at the histidine or serine residue, with the C-terminal tethered amino acid as well as therapeutic applications of those modified coagulation proteins.
Public/Granted literature
- US20140369992A1 C-Terminally Tethered Amino Acids and Their Fibrinolytic Therapeutic Uses Public/Granted day:2014-12-18
Information query
IPC分类:
