An auto-injection device for delivery of a fluid medicament is provided. The device includes an ampoule having a fluid medicament contained between first and second stoppers; a first sleeve movable along the longitudinal direction relative to the ampoule; a second sleeve at least partially surrounding the ampoule and movable along the longitudinal direction relative to the ampoule; and a needle. The first sleeve is movable along the longitudinal direction relative to the second sleeve and the ampoule between a first position and a second position. The needle is unexposed in the first position but exposed along the longitudinal direction in the second position. The second sleeve is also movable along the longitudinal direction relative to the ampoule between a first position and a second position. The needle is fluidly isolated from the medicament in the first position and is in fluid communication with the medicament in the second position.