Methods of forming earth-boring tools may involve positioning a blade frame segment in a mold, the blade frame segment comprising cutting-element-attachment locations distributed over a face of the blade frame segment, the mold comprising a longitudinal axis. A first cutting element may be secured to the blade frame segment at a first cutting-element-attachment location of the cutting-element-attachment locations. A second cutting element may be secured to the blade frame segment at a second, different cutting-element-attachment location of the cutting-element-attachment locations. The blade frame segment may be integrated into a blade of a plurality of radially extending blades of an earth-boring tool by forming a body of the earth-boring tool, including the blade, around the blade frame segment.