Invention Grant
US09580390B2 Indazole compounds as kinase inhibitors and method of treating cancer with same
有权
靛唑化合物作为激酶抑制剂及其治疗癌症的方法
- Patent Title: Indazole compounds as kinase inhibitors and method of treating cancer with same
- Patent Title (中): 靛唑化合物作为激酶抑制剂及其治疗癌症的方法
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Application No.: US14351381Application Date: 2012-10-12
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Publication No.: US09580390B2Publication Date: 2017-02-28
- Inventor: Heinz W. Pauls , Radoslaw Laufer , Yong Liu , Sze-Wan Li , Bryan T. Forrest , Yunhui Lang , Narendra Kumar B. Patel , Louise G. Edwards , Grace Ng , Peter Brent Sampson , Miklos Feher , Donald E. Awrey
- Applicant: University Health Network
- Applicant Address: CA Toronto
- Assignee: University Health Network
- Current Assignee: University Health Network
- Current Assignee Address: CA Toronto
- Agency: McCarter & English, LLP
- Agent Steven G. Davis; Wei Song
- International Application: PCT/CA2012/000955 WO 20121012
- International Announcement: WO2013/053051 WO 20130418
- Main IPC: C07D231/56
- IPC: C07D231/56 ; C07D401/14 ; C07D413/14 ; C07D409/12 ; C07D409/14 ; C07D405/14 ; C07D451/06 ; C07D491/107 ; C07D401/10 ; C07D401/12 ; C07D403/10 ; C07D413/04 ; C07D413/10 ; C07D493/10
Abstract:
The present teaching provide indazole compounds represented by Structural Formulae (I) or (I′) or a pharmaceutically acceptable salt thereof. Also described are pharmaceutical compositions and methods of use thereof as protein kinase inhibitors, such as TTK protein kinase, polo-like kinase 4 (PLK4) and Aurora kinases having anticancer activity against breast cancer cells, colon cancer cells, and ovarian cancer cells.
Public/Granted literature
- US20140371202A1 INDAZOLE COMPOUNDS AS KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME Public/Granted day:2014-12-18
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