Invention Grant
- Patent Title: Compounds, compositions, and methods for modulating ferroptosis and treating excitotoxic disorders
- Patent Title (中): 化合物，组合物和调节兴奋性毒性疾病的方法
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Application No.: US14390256Application Date: 2013-04-02
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Publication No.: US09580398B2Publication Date: 2017-02-28
- Inventor: Brent R. Stockwell , Scott J. Dixon , Rachid Skouta
- Applicant: The Trustees of Columbia University in the City of New York
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- Current Assignee Address: US NY New York
- Agency: Bryan Cave LLP
- International Application: PCT/US2013/035021 WO 20130402
- International Announcement: WO2013/152039 WO 20131010
- Main IPC: C07D213/80
- IPC: C07D213/80 ; C07C211/50 ; A61K31/44 ; A61K31/245 ; C07D309/14 ; C07C255/58 ; C07C271/16 ; C07C271/24 ; C07C271/28 ; C07C205/57 ; C07C205/58 ; C07D401/12 ; C07D239/26 ; C07C229/60 ; C07C233/54 ; C07C237/30 ; C07D295/088 ; C07D211/58 ; C07D295/30 ; C07D213/36 ; A61K31/325 ; A61K31/351 ; A61K31/4465 ; A61K31/495 ; A61K31/5375 ; A61K45/06 ; C07C69/78 ; C07D295/192
Abstract:
The present invention provides, inter alia, a compound having the structure: (Formula (I). Also provided are compositions containing a pharmaceutically acceptable carrier and a compound according to the present invention. Further provided are methods for treating or ameliorating the effects of an excitotoxic disorder in a subject, methods of modulating ferroptosis in a subject, methods of reducing reactive oxygen species (ROS) in a cell, and methods for treating or ameliorating the effects of a neurodegenerative disease.
Public/Granted literature
- US20150079035A1 Compounds, Compositions, and Methods For Modulating Ferroptosis and Treating Excitotoxic Disorders Public/Granted day:2015-03-19
Information query
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