Invention Grant
- Patent Title: Substituted pyrrolidines as ROS tyrosine kinase inhibitors
- Patent Title (中): 取代的吡咯烷作为ROS酪氨酸激酶抑制剂
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Application No.: US14402198Application Date: 2013-05-29
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Publication No.: US09580413B2Publication Date: 2017-02-28
- Inventor: Katsutoshi Hori , Hiroki Hayase , Tomohiro Terada
- Applicant: NIPPON SHINYAKU CO., LTD.
- Applicant Address: JP Kyoto
- Assignee: NIPPON SHINYAKU CO., LTD.
- Current Assignee: NIPPON SHINYAKU CO., LTD.
- Current Assignee Address: JP Kyoto
- Priority: JP2012-122715 20120530
- International Application: PCT/JP2013/064933 WO 20130529
- International Announcement: WO2013/180183 WO 20131205
- Main IPC: A61K31/4025
- IPC: A61K31/4025 ; C07D295/02 ; C07D417/14 ; C07D471/04

Abstract:
The main purpose of the invention is to provide a novel aromatic heterocyclic derivative or a pharmaceutically acceptable salt thereof. Examples of the invention include aromatic heterocyclic derivatives represented by general formula [1] and pharmaceutically acceptable salts thereof. In formula [1]: R1 represents phenyl optionally substituted with one or two groups selected from the group consisting of halogens, as well as alkyls and alkoxys optionally substituted by halogens; R2 represents hydrogen, an alkyl, cycloalkyl, or alkoxy optionally substituted by a halogen, or a heteroaryl optionally substituted by an alkyl; X represents CR3, and Y represents N or CR4, or X represents N, and Y represents CR4; and Z represents CR5 or N.
Public/Granted literature
- US20150152095A1 AROMATIC HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL Public/Granted day:2015-06-04
Information query
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