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US09580424B2 Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt 有权
反式-7-氧代-6-（磺酰氧基）-1,6-二氮杂双环[3,2,1]辛烷-2-甲酰胺钠盐的结晶形式

Crystalline forms of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide sodium salt
Abstract:
The present invention relates to novel crystalline forms of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104) thereof. The present invention relates to compositions comprising a crystalline form of sodium salt of trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide (e.g., NXL-104) alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil). Processes for the preparation of the crystalline forms and methods of treating bacterial infections by administering the crystalline forms alone or in combination with an antibacterial agent (e.g., ceftaroline fosamil) are also described.
Abstract(Chinese):

本发明涉及反式-7-氧代-6-（磺酰氧基）-1,6-二氮杂双环[3,2,1]辛烷-2-甲酰胺（例如，NXL-104）的钠盐的新结晶形式。 本发明涉及包含反式-7-氧代-6-（磺酰氧基）-1,6-二氮杂双环[3,2,1]辛烷-2-甲酰胺（例如，NXL-104）的钠盐的结晶形式的组合物， 单独或与抗菌剂（例如头孢洛林粉剂）组合。 还描述了通过单独施用结晶形式或与抗菌剂（例如头孢洛林粉剂）联合来制备结晶形式和治疗细菌感染的方法的方法。

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