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US09580442B2 Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors 有权
三环杂环化合物作为磷酸肌醇3-激酶抑制剂

Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
Abstract:
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N—H, N—(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)mY; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110δ, and therefore have utility in therapy.
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