Invention Grant
US09580442B2 Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
有权
三环杂环化合物作为磷酸肌醇3-激酶抑制剂
- Patent Title: Tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitors
- Patent Title (中): 三环杂环化合物作为磷酸肌醇3-激酶抑制剂
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Application No.: US14920410Application Date: 2015-10-22
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Publication No.: US09580442B2Publication Date: 2017-02-28
- Inventor: Stephen J. Shuttleworth , Alexander R. Liam Cecil , Thomas J. Hill , Franck A. Silva
- Applicant: Karus Therapeutics Limited
- Applicant Address: GB Oxfordshire
- Assignee: Karus Therapeutics Limited
- Current Assignee: Karus Therapeutics Limited
- Current Assignee Address: GB Oxfordshire
- Agency: Goodwin Procter LLP
- Priority: GB0914594.7 20090820; GB1005584.6 20100401
- Main IPC: C07D495/14
- IPC: C07D495/14 ; C07D491/147 ; C07D519/00

Abstract:
Compounds of formula (I) or a pharmaceutically acceptable salt thereof, wherein: W is O, N—H, N—(C1-C10 alkyl) or S; each X is independently CH or N; R1 is a 5 to 7-membered saturated or unsaturated, optionally substituted heterocycle containing at least 1 heteroatom selected from N or O; R2 is (LQ)mY; and each R3 is independently H, C1-C10 alkyl, aryl or heteroaryl, are surprisingly found to be inhibitors of PI3K-p110δ, and therefore have utility in therapy.
Public/Granted literature
- US20160108057A1 TRICYCLIC HETEROCYCLIC COMPOUNDS AS PHOSPHOINOSITIDE 3-KINASE INHIBITORS Public/Granted day:2016-04-21
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