Invention Grant
- Patent Title: Compositions and methods for the production of pyrimidine and pyridine compounds with BTK inhibitory activity
- Patent Title (中): 用BTK抑制活性生产嘧啶和吡啶化合物的组合物和方法
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Application No.: US14727050Application Date: 2015-06-01
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Publication No.: US09580449B2Publication Date: 2017-02-28
- Inventor: Brian L. Hodous , Lesley Liu-Bujalski , Reinaldo Jones , Donald Bankston , Theresa L. Johnson , Igor Mochalkin , Ngan Nguyen , Hui Qiu , Andreas Goutopoulos , Nadia Brugger
- Applicant: Merck Patent GmbH
- Applicant Address: DE Darmstadt
- Assignee: Merck Patent GmbH
- Current Assignee: Merck Patent GmbH
- Current Assignee Address: DE Darmstadt
- Agency: EMD Serono Research and Development Institute
- Agent Dwight D. Kim
- Main IPC: A61K31/506
- IPC: A61K31/506 ; C07D401/12 ; C07F5/02 ; C07D213/68 ; C07D213/73 ; C07D213/74 ; C07D239/47 ; C07D239/48 ; C07D401/04 ; C07D401/14 ; C07D403/04 ; C07D403/12 ; C07D403/14 ; C07D413/12 ; C07D413/14 ; C07D495/04 ; C07D405/14 ; C07D451/02 ; C07D471/10 ; A61K31/505 ; A61K31/513 ; A61K31/5377 ; A61K31/55
Abstract:
The present invention provides novel pyrimidine and pyridine compounds according to Formula (I), Formula (II), Formula (III), Formula (IV) and Formula (V) their manufacture and use for the treatment of hyperproliferative diseases including, but not limited to, cancer, lupus, allergic disorders, Sjogren's disease and rheumatoid arthritis. In preferred embodiments, the present invention describes irreversible kinase inhibitors including, but not limited to, inhibitors of Bruton's tyrosine kinase.
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