Invention Grant
- Patent Title: Method for purifying active polypeptides or immunoconjugates
- Patent Title (中): 纯化活性多肽或免疫缀合物的方法
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Application No.: US13813083Application Date: 2011-07-27
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Publication No.: US09580461B2Publication Date: 2017-02-28
- Inventor: Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
- Applicant: Thomas Linke , William K. Wang , Ambarish Shah , Hasige Sathish , Alan Hunter , Christopher Thompson
- Applicant Address: US MD Gaithersburg
- Assignee: MedImmune, LLC
- Current Assignee: MedImmune, LLC
- Current Assignee Address: US MD Gaithersburg
- International Application: PCT/US2011/045524 WO 20110727
- International Announcement: WO2012/015912 WO 20120202
- Main IPC: A61K49/00
- IPC: A61K49/00 ; A61K39/395 ; A61K39/00 ; C07K1/18 ; B01D15/16 ; B01D15/36 ; B01J41/14 ; B01J41/20 ; C07K17/02 ; A61K47/48 ; C07K16/28
Abstract:
The present invention provides methods for isolating an active polypeptide or immunoconjugate by purification of a solution containing both the active polypeptide or immunoconjugate and an acidic variant thereof, such as a deamidated variant, using anion exchange chromatography.
Public/Granted literature
- US20130202626A1 METHOD FOR PURIFYING ACTIVE POLYPEPTIDES OR IMMUNOCONJUGATES Public/Granted day:2013-08-08
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