Invention Grant
US09580475B2 Computationally optimized broadly reactive antigens for H1N1 influenza
有权
用于H1N1流感的计算优化的广泛反应性抗原
- Patent Title: Computationally optimized broadly reactive antigens for H1N1 influenza
- Patent Title (中): 用于H1N1流感的计算优化的广泛反应性抗原
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Application No.: US14126550Application Date: 2012-06-20
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Publication No.: US09580475B2Publication Date: 2017-02-28
- Inventor: Ted M. Ross , Corey J. Crevar
- Applicant: Ted M. Ross , Corey J. Crevar
- Applicant Address: US PA Pittsburgh
- Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
- Current Assignee Address: US PA Pittsburgh
- Agency: Klarquist Sparkman, LLP
- International Application: PCT/US2012/043347 WO 20120620
- International Announcement: WO2012/177760 WO 20121227
- Main IPC: C07K14/005
- IPC: C07K14/005 ; A61K39/145 ; A61K39/12 ; A61K39/00
Abstract:
Described herein is the generation of optimized H1N1 influenza HA polypeptides for eliciting a broadly reactive immune response to H1N1 influenza virus isolates. The optimized HA polypeptides were developed through a series of HA protein alignments, and subsequent generation of consensus sequences, based on selected H1N1 viruses isolated from 1918-2011. Provided herein are optimized H1N1 HA polypeptides, and compositions, fusion proteins and VLPs comprising the HA polypeptides. Further provided are codon-optimized nucleic acid sequences encoding the HA polypeptides. Methods of eliciting an immune response against influenza virus in a subject are also provided by the present disclosure.
Public/Granted literature
- US20140127248A1 COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR H1N1 INFLUENZA Public/Granted day:2014-05-08
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