Invention Grant
US09580483B2 Methods of using compositions comprising variants and fusions of FGF19 polypeptides for treatment of diabetes
有权
使用包含FGF19多肽的变体和融合物的组合物用于治疗糖尿病的方法
- Patent Title: Methods of using compositions comprising variants and fusions of FGF19 polypeptides for treatment of diabetes
- Patent Title (中): 使用包含FGF19多肽的变体和融合物的组合物用于治疗糖尿病的方法
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Application No.: US14743851Application Date: 2015-06-18
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Publication No.: US09580483B2Publication Date: 2017-02-28
- Inventor: Lei Ling , Darrin Anthony Lindhout
- Applicant: NGM Biopharmaceuticals, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: NGM Biopharmaceuticals, Inc.
- Current Assignee: NGM Biopharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Jones Day
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/50 ; G01N33/50 ; A61K31/14 ; A61K31/155 ; A61K45/06 ; A61K31/785 ; A61K38/00
Abstract:
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21), and variants or fusions of fibroblast growth factor 19 (FGF19) and/or fibroblast growth factor 21 (FGF21) proteins and peptide sequences (and peptidomimetics), having one or more activities, such as glucose lowering activity, and methods for and uses in treatment of hyperglycemia and other disorders.
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