Invention Grant
- Patent Title: Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof
- Patent Title (中): 减毒的重组甲病毒不能在蚊子中复制及其用途
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Application No.: US13855960Application Date: 2013-04-03
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Publication No.: US09580690B2Publication Date: 2017-02-28
- Inventor: Scott C. Weaver , Ilya V. Frolov , Elena Frolova
- Applicant: The Board of Regents of the University of Texas System
- Applicant Address: US TX Austin
- Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM
- Current Assignee Address: US TX Austin
- Agency: Norton Rose Fulbright US LLP
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/12 ; C12N15/86 ; A61K39/00
Abstract:
The present invention discloses an attenuated recombinant alphavirus that is incapable of replicating in mosquito cells and of transmission by mosquito vectors. These attenuated alphavirus may include but is not limited to Western Equine Encephalitis virus, Eastern equine encephalitis virus, Venezuelan equine encephalitis virus or Chikungunya virus. The present invention also discloses the method of generating such alphaviruses and their use as immunogenic compositions.
Public/Granted literature
- US20140010841A1 Attenuated Recombinant Alphaviruses Incapable of Replicating in Mosquitoes and Uses Thereof Public/Granted day:2014-01-09
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