Invention Grant
- Patent Title: Synthesis of long fish probes
- Patent Title (中): 合成长鱼探针
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Application No.: US14146216Application Date: 2014-01-02
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Publication No.: US09580746B2Publication Date: 2017-02-28
- Inventor: Emily Marine Leproust , Siyuan Chen , Michael Ruvolo
- Applicant: Agilent Technologies, Inc.
- Applicant Address: US CA Santa Clara
- Assignee: Agilent Technologies, Inc.
- Current Assignee: Agilent Technologies, Inc.
- Current Assignee Address: US CA Santa Clara
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G06F19/20
Abstract:
A method comprising: synthesizing a set of overlapping oligonucleotides that comprises probe sequences that hybridize to unique sequences in a chromosome, assembling the overlapping oligonucleotides in a way that produces one or more double stranded polynucleotides that each comprises multiple probe sequences, labeling the one or more double stranded polynucleotides to produce one or more labeled probes, and hybridizing the labeled probes to an intact chromosome, in situ, is provided.
Public/Granted literature
- US20140256575A1 SYNTHESIS OF LONG FISH PROBES Public/Granted day:2014-09-11
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