A turbine blade for a gas turbine engine with an airfoil portion defined by a perimeter wall surrounding at least one enclosure, the perimeter wall having a plurality of cooling holes defined therethrough and providing fluid communication between the at least one enclosure and a gaspath of the gas turbine engine. The plurality of cooling holes includes at least one set of holes selected from the group consisting of a first set, a second set, a third set, a fourth set, a fifth set and a sixth set, wherein the first, second, third, fourth, fifth and sixth sets of holes respectively include the holes numbered A1 to A8, B1 to B10, C1 to C9, D1 to D6, E1 to E7 and F1 to F6 each located such that a central axis thereof extends through the respective point 1 and point 2 having a nominal location in accordance with the X, Y, Z Cartesian coordinate values set forth in Table 3.