A method includes cycling through a plurality of microphone and speaker combinations in a mobile device in response to the mobile device being placed in speakerphone mode. The mobile device includes a plurality of microphones and at least one speaker. The method obtains acoustic echo data from an echo canceller for each microphone and speaker combination, calculates an acoustic isolation value for each combination and then selects a microphone and speaker combination based on the acoustic isolation value. The method may also include determining an echo spectrum for each microphone and speaker combination using the obtained acoustic echo data, and select an echo control profile based on a characteristic of the echo spectrum. The echo control profile is selected to further improve acoustic isolation for the selected microphone and speaker combination.