Invention Grant
- Patent Title: Genetically modified major histocompatibility complex mice
- Patent Title (中): 转基因主要组织相容性复合体小鼠
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Application No.: US14455237Application Date: 2014-08-08
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Publication No.: US09585373B2Publication Date: 2017-03-07
- Inventor: Lynn Macdonald , Andrew J Murphy , Naxin Tu , Cagan Gurer , Vera Voronina , Sean Stevens
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee: Regeneron Pharmaceuticals, Inc.
- Current Assignee Address: US NY Tarrytown
- Agency: Brownstein Hyatt Farber Schreck, LLP
- Agent Rita S. Wu; Margarita Zippin
- Main IPC: A01K67/027
- IPC: A01K67/027 ; C12N5/06 ; C12N15/00 ; C12P21/08 ; C07K14/74 ; C12N15/85
Abstract:
The invention provides genetically modified non-human animals that express a humanized MHC II protein (humanized MHC II α and β polypeptides), as well as embryos, cells, and tissues comprising the humanized MHC II protein. Also provided are constructs for and methods of making the genetically modified non-human animals. Methods of using the genetically modified non-human animals to study various aspects of the human immune system are provided.
Public/Granted literature
- US20150040253A1 GENETICALLY MODIFIED MAJOR HISTOCOMPATIBILITY COMPLEX MICE Public/Granted day:2015-02-05
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