Invention Grant
US09585865B2 Small molecule modulators of the cold and menthol receptor TRPM8
有权
冷和薄荷脑受体TRPM8的小分子调节剂
- Patent Title: Small molecule modulators of the cold and menthol receptor TRPM8
- Patent Title (中): 冷和薄荷脑受体TRPM8的小分子调节剂
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Application No.: US14563793Application Date: 2014-12-08
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Publication No.: US09585865B2Publication Date: 2017-03-07
- Inventor: Michael Krohn , Holger Zinke
- Applicant: B.R.A.I.N. Biotechnology Research and Information Network AG
- Applicant Address: DE Zwingenberg
- Assignee: B.R.A.I.N. Biotechnology Research and Information Network AG
- Current Assignee: B.R.A.I.N. Biotechnology Research and Information Network AG
- Current Assignee Address: DE Zwingenberg
- Agency: Morrison & Foerster LLP
- Priority: EP11157329 20110308
- Main IPC: A61K31/35
- IPC: A61K31/35 ; A61K31/352 ; A61K8/41 ; A61K8/49 ; A61K31/00 ; A61K31/136 ; A61K31/137 ; A61K31/351 ; A61K31/4439 ; A61K31/496 ; A61K31/513 ; A61Q5/00 ; A61Q11/00 ; A61Q17/02 ; A61Q19/00 ; A61K31/353 ; C07D311/36
Abstract:
The present invention relates to the use of compounds which are capable of producing a cooling sensation when they are brought into contact with the human body. In particular, the present invention relates to the use of compounds modulating TRPM8, and optionally to the use of compounds selectively exhibiting agonist activity at the TRPM8 channel. Such compounds have applications in many fields, particularly in oral and personal hygiene products and foodstuffs, but also in pharmaceutical composition products, cosmetics, textile products and packaging products. The present invention further relates to products containing such compounds and to the medical use of such compounds.
Public/Granted literature
- US20150094365A1 SMALL MOLECULE MODULATORS OF THE COLD AND MENTHOL RECEPTOR TRPM8 Public/Granted day:2015-04-02
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