Invention Grant
- Patent Title: TRPM8 antagonists
- Patent Title (中): TRPM8拮抗剂
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Application No.: US14366796Application Date: 2012-12-19
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Publication No.: US09585875B2Publication Date: 2017-03-07
- Inventor: Alessio Moriconi , Gianluca Bianchini , Sandro Colagioia , Laura Brandolini , Andrea Aramini , Chiara Liberati , Silvia Bovolenta
- Applicant: Dompé S.P.A.
- Applicant Address: IT Milan
- Assignee: DOMPÉ FARMACEUTICI S.P.A.
- Current Assignee: DOMPÉ FARMACEUTICI S.P.A.
- Current Assignee Address: IT Milan
- Agency: Fish & Richardson P.C.
- Priority: EP11194365 20111219; EP12178327 20120727
- International Application: PCT/EP2012/076147 WO 20121219
- International Announcement: WO2013/092711 WO 20130627
- Main IPC: A61K31/4439
- IPC: A61K31/4439 ; A61K31/427 ; A61K31/426 ; A61K31/4245 ; A61K31/421 ; C07D277/56 ; C07D417/04 ; C07D417/10 ; C07D417/12 ; C07D263/42 ; A61K31/472
Abstract:
The invention relates to compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (TRPM8), and having formula (I). Said compounds are useful in the treatment of diseases associated with activity of TRPM8 such as pain, inflammation, ischaemia, neurodegeneration, stroke, psychiatric disorders, itch, irritable bowel diseases, cold induced and/or exhacerbated respiratory disorders and urological disorders.
Public/Granted literature
- US20140371276A1 TRPM8 ANTAGONISTS Public/Granted day:2014-12-18
Information query
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