Invention Grant
- Patent Title: Cyclic amino compounds for use in the treatment of cardiac disorders
- Patent Title (中): 用于治疗心脏疾病的环状氨基化合物
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Application No.: US14549414Application Date: 2014-11-20
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Publication No.: US09585880B2Publication Date: 2017-03-07
- Inventor: Jo Klaveness , Kjetil Tasken
- Applicant: Universitetet I Oslo
- Applicant Address: NO Blindern
- Assignee: Universitetet I Oslo
- Current Assignee: Universitetet I Oslo
- Current Assignee Address: NO Blindern
- Agency: Dorsey & Whitney LLP
- Priority: GB1320506.7 20131120
- Main IPC: A61K31/44
- IPC: A61K31/44 ; A61K31/472 ; A61K31/4035 ; A61K31/4439
Abstract:
The present invention relates to tertiary amines of formula (I) for use in therapy, particularly for use in treating cardiovascular disorders. The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP18δ) binding to the PKA substrate phospholamban. The compounds share a tri(alkylaryl/alkylheteroaryl) amine structure.
Public/Granted literature
- US20150141456A1 CYCLIC AMINO COMPOUNDS FOR USE IN THE TREATMENT OF CARDIAC DISORDERS Public/Granted day:2015-05-21
Information query
