Invention Grant
- Patent Title: Neprilysin inhibitors
- Patent Title (中): Neprilysin抑制剂
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Application No.: US14608405Application Date: 2015-01-29
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Publication No.: US09585882B2Publication Date: 2017-03-07
- Inventor: Melissa Fleury , Anne-Marie Beausoliel , Adam D. Hughes , Daniel D. Long , Donna A. A. Wilton
- Applicant: Melissa Fleury , Anne-Marie Beausoliel , Adam D. Hughes , Daniel D. Long , Donna A. A. Wilton
- Applicant Address: US CA South San Francisco
- Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee: Theravance Biopharma R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Wendy Petka
- Main IPC: A61K31/505
- IPC: A61K31/505 ; A61K31/4192 ; A61K45/06 ; A61K31/415 ; C07C229/08 ; C07C271/22 ; C07D231/14 ; C07D263/34 ; C07D249/10 ; C07D307/24 ; C07D207/16 ; C07D249/04 ; A61K31/421 ; C07D271/07 ; A61K31/4245 ; C07D213/81 ; A61K31/44 ; C07D239/28 ; A61K31/4196 ; C07D405/12 ; C07D403/12 ; C07D239/42 ; C07D249/14 ; C07D261/10 ; C07D213/56
Abstract:
In one aspect, the invention relates to compounds having the formula I: where R1, R2a, R2b, and R3-R6 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
Public/Granted literature
- US20150209352A1 NEPRILYSIN INHIBITORS Public/Granted day:2015-07-30
Information query
