Invention Grant
- Patent Title: Reduction of toxicity of multi-targeting antifolates
- Patent Title (中): 降低多靶点抗叶酸剂的毒性
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Application No.: US14811905Application Date: 2015-07-29
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Publication No.: US09585888B2Publication Date: 2017-03-07
- Inventor: Bengt Gustavsson , Göran Carlsson
- Applicant: Isofol Medical AB
- Applicant Address: SE Gothenburg
- Assignee: ISOFOL MEDICAL AB
- Current Assignee: ISOFOL MEDICAL AB
- Current Assignee Address: SE Gothenburg
- Agency: Harness, Dickey and Pierce, P.L.C.
- Priority: SE0303526-8 20031222
- Main IPC: A61K31/517
- IPC: A61K31/517 ; A61K31/519 ; A61K45/06
Abstract:
The use of tetrahydrofolate, methylene-tetrahydrofolate and/or methyl-tetrahydrofolate, and at least one multi-targeting antifolate, for the manufacture of a pharmaceutical composition for the treatment of cancer is disclosed. By combining the multi-targeting antifolate with tetrahydrofolate, methylene-tetrahydrofolate and/or methyl-tetrahydrofolate, it is possible to remarkably reduce toxic side-effects without diminishing the anti-tumor action of the drugs. A pharmaceutical composition, a kit comprising the pharmaceutical composition as well as a method for the treatment of cancer are also disclosed.
Public/Granted literature
- US20150328218A1 Reduction Of Toxicity Of Multi-Targeting Antifolates Public/Granted day:2015-11-19
Information query
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