Invention Grant
- Patent Title: EGFR-based peptides
- Patent Title (中): 基于EGFR的肽
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Application No.: US13879143Application Date: 2011-10-12
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Publication No.: US09585938B2Publication Date: 2017-03-07
- Inventor: Joyce A. Schroeder , Benjamin G. Bitler , Aarthi Goverdhan
- Applicant: Joyce A. Schroeder , Benjamin G. Bitler , Aarthi Goverdhan
- Applicant Address: US AZ Tuscon
- Assignee: ARIZONA CANCER THERAPEUTICS, LLC
- Current Assignee: ARIZONA CANCER THERAPEUTICS, LLC
- Current Assignee Address: US AZ Tuscon
- International Application: PCT/US2011/055894 WO 20111012
- International Announcement: WO2012/051247 WO 20120419
- Main IPC: A61K45/00
- IPC: A61K45/00 ; A61K38/17 ; C07K14/71 ; A61K45/06 ; A61K38/00
Abstract:
Observations regarding the role of MUC1 in promoting the nuclear accumulation of EGFR led us to propose the development of peptides to block nuclear accumulation of EGFR as a means to block breast cancer progression. One exemplary peptide, the ENLS1 peptide, promotes cell death in breast cancer cell lines. Studies in the MMTV-pyMT mouse model of breast cancer demonstrate significant anti-tumor activity.
Public/Granted literature
- US20130251727A1 EGFR-BASED PEPTIDES Public/Granted day:2013-09-26
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