Invention Grant
US09585957B2 Adenosine receptor agonists and antagonists to modulate T cell responses
有权
腺苷受体激动剂和拮抗剂调节T细胞应答
- Patent Title: Adenosine receptor agonists and antagonists to modulate T cell responses
- Patent Title (中): 腺苷受体激动剂和拮抗剂调节T细胞应答
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Application No.: US12676741Application Date: 2008-09-08
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Publication No.: US09585957B2Publication Date: 2017-03-07
- Inventor: Jonathan D Powell , Charles George Drake , Paul Zarek
- Applicant: Jonathan D Powell , Charles George Drake , Paul Zarek
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Johns Hopkins Technology Transfer
- International Application: PCT/US2008/075610 WO 20080908
- International Announcement: WO2009/033161 WO 20090312
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61P37/00 ; A61P35/00 ; A61K45/06 ; A61K39/395
Abstract:
Described are uses of A2a adenosine receptor antagonists and agonists to provide long term modulation of immune responses. A2a receptor antagonists in particular are provided to enhance immune responses by reducing T-cell mediated tolerance to antigenic stimuli and agonists are provided to enhance effectiveness of immunosuppressive agents. The application provides methods of treatment and prevention based on the long term effects of the compounds on T cell responses.
Public/Granted literature
- US20110027295A1 Adenosine Receptor Agonists and Antagonists to Modulate T Cell Responses Public/Granted day:2011-02-03
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