Invention Grant
US09585963B2 Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
有权
包含可酶切的阿片样物质前药及其抑制剂的组合物
- Patent Title: Compositions comprising enzyme-cleavable opioid prodrugs and inhibitors thereof
- Patent Title (中): 包含可酶切的阿片样物质前药及其抑制剂的组合物
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Application No.: US14692526Application Date: 2015-04-21
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Publication No.: US09585963B2Publication Date: 2017-03-07
- Inventor: Thomas E. Jenkins , Craig O. Husfeld , Julie D. Seroogy , Jonathan W. Wray
- Applicant: Signature Therapeutics, Inc.
- Applicant Address: US CA La Jolla
- Assignee: Signature Therapeutics, Inc.
- Current Assignee: Signature Therapeutics, Inc.
- Current Assignee Address: US CA La Jolla
- Agency: Bozicevic, Field & Francis LLP
- Agent Khin K. Chin; Carol L. Francis
- Main IPC: A61K31/74
- IPC: A61K31/74 ; A61K47/48 ; A61K9/51 ; A61K31/485 ; C07D489/02 ; C07D489/08 ; C12Q1/37 ; G01N33/50 ; G01N33/94
Abstract:
Pharmaceutical compositions and their methods of use are provided, where the pharmaceutical compositions comprise an opioid prodrug that provides enzymatically-controlled release of an opioid, and an enzyme inhibitor that interacts with the enzyme(s) that mediates the enzymatically-controlled release of the opioid from the opioid prodrug so as to attenuate enzymatic cleavage of the opioid prodrug.
Public/Granted literature
- US20150297736A1 Compositions Comprising Enzyme-Cleavable Opioid Prodrugs and Inhibitors Thereof Public/Granted day:2015-10-22
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