A waste processing system includes a receptacle for waste material, including bags of waste, and a liquid to be mixed with the waste. The receptacle has an inlet, a waste outlet, and at least one nozzle opening with at least one slicing nozzle that sprays a slicing fluid under pressure sufficient to manipulate the waste material. The system includes a pump for chopping the waste material and circulating and mixing the liquid and waste material, a waste inlet conduit, and a waste outlet conduit. The receptacle, pump, waste inlet and waste outlet conduits define a closed, pressurized waste processing circuit for circulating the liquid and waste. The system also includes a heating system to heat the liquid and waste to effect biological neutralization of the liquid and waste material, and all surfaces of the waste processing system with which the waste material being processed comes into contact.