Invention Grant
- Patent Title: Crystalline anhydrous form of Cabazitaxel, process for the preparation and pharmaceutical compositions thereof
- Patent Title (中): 卡伐他汀的结晶无水形式，其制备方法及其药物组合物
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Application No.: US15030620Application Date: 2014-10-09
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Publication No.: US09586919B2Publication Date: 2017-03-07
- Inventor: Walter Cabri , Daniele Ciceri , Luca Domenighini , Andrea Gambini , Federico Peterlongo
- Applicant: INDENA S.P.A.
- Applicant Address: IT Milan
- Assignee: INDENA S.P.A.
- Current Assignee: INDENA S.P.A.
- Current Assignee Address: IT Milan
- Agency: Silvia Salvadori, P.C.
- Agent Silvia Salvadori
- Priority: EP13189949 20131023
- International Application: PCT/EP2014/071601 WO 20141009
- International Announcement: WO2015/058961 WO 20150430
- Main IPC: C07D305/14
- IPC: C07D305/14
Abstract:
The present invention relates to a new anhydrous crystalline form of Cabazitaxel of formula (I), designated as form H. A further object of the present invention is a processes for the preparation of the above mentioned form H by recrystallization of Cabazitaxel from a mixture of decanoyl- and octanoyl triglycerides or from glycerol trioctanoate. Form H of Cabazitaxel is useful for the preparation of Cabazitaxel, Cabazitaxel salts, and polymorphic forms thereof. It is also particularly useful as a medicament, especially for the treatment of cancers.
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