Invention Grant
- Patent Title: Apoptosis signal-regulating kinase inhibitors
- Patent Title (中): 细胞凋亡信号调节激酶抑制剂
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Application No.: US14716526Application Date: 2015-05-19
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Publication No.: US09586932B2Publication Date: 2017-03-07
- Inventor: Michael Graupe , Keith Koch , Britton K. Corkey , Gregory Notte , Lawrence S. Melvin, Jr.
- Applicant: Gilead Sciences, Inc.
- Applicant Address: US CA Foster City
- Assignee: Gilead Sciences, Inc.
- Current Assignee: Gilead Sciences, Inc.
- Current Assignee Address: US CA Foster City
- Agent Briana Barron
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D401/12 ; C07D471/04 ; C07D491/048 ; C07D417/14 ; C07D405/14 ; C07D413/12 ; C07D413/14
Abstract:
The present invention relates to compounds of Formula (I): wherein X1, X2, X3, X4, X5, X6, X7, X8, R1, R2, R3 are as defined above. The compounds have apoptosis signal-regulating kinase (“ASK1”) inhibitory activity, and are thus useful in the treatment of ASK1-mediated conditions, including autoimmune disorders, inflammatory diseases, cardiovascular diseases and neurodegenerative diseases. The invention also relates to pharmaceutical compositions comprising one or more of the compounds of Formula (I), and to methods of preparing the compounds of Formula (I).
Public/Granted literature
- US20160130251A1 APOPTOSIS SIGNAL-REGULATING KINASE INHIBITORS Public/Granted day:2016-05-12
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