Invention Grant
US09586963B2 Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists
有权
6-取代三唑并噻嗪类衍生物作为Rev-Erb激动剂
- Patent Title: Derivatives of 6-substituted triazolopyridazines as Rev-Erb agonists
- Patent Title (中): 6-取代三唑并噻嗪类衍生物作为Rev-Erb激动剂
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Application No.: US14344255Application Date: 2012-09-27
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Publication No.: US09586963B2Publication Date: 2017-03-07
- Inventor: Maryline Bourotte , Jean-Francois Delhomel , Mathieu Dubernet , Marie-Helene Gouy
- Applicant: GENFIT
- Applicant Address: FR Loos
- Assignee: Genfit
- Current Assignee: Genfit
- Current Assignee Address: FR Loos
- Agency: Cesari and McKenna LLP
- Priority: EP11306234 20110927; EP12163795 20120411
- International Application: PCT/EP2012/069014 WO 20120927
- International Announcement: WO2013/045519 WO 20130404
- Main IPC: C07D487/04
- IPC: C07D487/04
Abstract:
The present invention provides novel 6-substituted [1,2,4]triazolo[4,3-b]pyridazines that are agonists of Rev-Erb. These compounds, and pharmaceutical compositions comprising the same, are suitable means for treating any disease wherein the activation of Rev-Erb has therapeutic effects, for instance in inflammatory and circadian rhythm-related disorders or cardiometabolic diseases.
Public/Granted literature
- US20150038503A1 DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS Public/Granted day:2015-02-05
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