Invention Grant
US09586968B2 Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
有权
在电压门控钠通道中具有选择性活性的双环胺取代的N-苯磺酰胺化合物
- Patent Title: Bicycloamine-substituted-N-benzenesulfonamide compounds with selective activity in voltage-gated sodium channels
- Patent Title (中): 在电压门控钠通道中具有选择性活性的双环胺取代的N-苯磺酰胺化合物
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Application No.: US15038805Application Date: 2014-11-24
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Publication No.: US09586968B2Publication Date: 2017-03-07
- Inventor: Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Dansu Li , Xiu Wang , Xuanjia Peng
- Applicant: Merck Sharp & Dohme Corp. , Dansu Li , Mark E. Layton , Anthony J. Roecker , Melissa Egbertson , Kristen L. G. Jones , Xiu Wang , Xuanjia Peng
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent H. Eric Fischer; John C. Todaro
- Priority: WOPCT/CN2013/001476 20131129
- International Application: PCT/US2014/067001 WO 20141124
- International Announcement: WO2015/080988 WO 20150604
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/407 ; C07D471/04 ; A61K31/4353 ; C07D491/20 ; C07D487/10 ; C07D277/52 ; C07D213/76 ; C07D239/42 ; C07D237/20 ; C07D285/135
Abstract:
Disclosed are compounds of Formula A-a, or a salt thereof: Where “B1” and “R1” through “R5” are as defined herein, which compounds have properties for blocking Nav 1.7 ion channels found in peripheral and sympathetic neurons. Also described are pharmaceutical formulations comprising the compounds of Formula A-a or their salts, and methods of treating neuropathic pain disorders using the same.
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