Invention Grant
US09587002B2 Sequence of nucleotides and peptides GSE 24.2 of dyskerin, which can induce telomerase activity, method for obtaining same, therapeutic compositions and applications thereof
有权
核苷酸和肽的序列可以诱导端粒酶活性的dyskerin的GSE 24.2，其获得方法，治疗组合物及其应用
- Patent Title: Sequence of nucleotides and peptides GSE 24.2 of dyskerin, which can induce telomerase activity, method for obtaining same, therapeutic compositions and applications thereof
- Patent Title (中): 核苷酸和肽的序列可以诱导端粒酶活性的dyskerin的GSE 24.2，其获得方法，治疗组合物及其应用
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Application No.: US14740890Application Date: 2015-06-16
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Publication No.: US09587002B2Publication Date: 2017-03-07
- Inventor: Rosario Perona Abellon , Rosario Machado Pinilla , Leandro Sastre Garzon , Isabel Sanchez Perez , Jose Ramon Murguia Ibanez
- Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS , UNIVERSIDAD AUTONOMA DE MADRID—FUNDACION GENERAL , UNIVERSIDAD POLITECNICA DE VALENCIA
- Applicant Address: ES Madrid ES Madrid ES Valencia
- Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS,UNIVERSIDAD AUTONOMA DE MADRID—FUNDACION GENERAL,UNIVERSIDAD POLITECNICA DE VALENCIA
- Current Assignee: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS,UNIVERSIDAD AUTONOMA DE MADRID—FUNDACION GENERAL,UNIVERSIDAD POLITECNICA DE VALENCIA
- Current Assignee Address: ES Madrid ES Madrid ES Valencia
- Agency: Leason Ellis LLP
- Priority: ES200502511 20051014
- Main IPC: A61K48/00
- IPC: A61K48/00 ; C07K14/47 ; C12N9/12 ; A61K38/00
Abstract:
This invention relates to a compound that induces or activates telomerase activity based on the nucleotide sequence of the GSE 24.2 fragment of dyskerin or the protein or peptide sequence encoded by said nucleotide sequence. Another part of the invention relates to vectors that comprise said sequence and cells transformed thereby, and pharmaceutical compositions that contain all these elements. These compositions may be used in the treatment of diseases from the following group: ageing or acceleration of ageing, neurodegenerative diseases and dyskeratosis congenita.
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