Invention Grant
US09587021B2 CD3-binding molecules capable of binding to human and non-human CD3
有权
能结合人和非人CD3的CD3结合分子
- Patent Title: CD3-binding molecules capable of binding to human and non-human CD3
- Patent Title (中): 能结合人和非人CD3的CD3结合分子
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Application No.: US14118523Application Date: 2012-05-16
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Publication No.: US09587021B2Publication Date: 2017-03-07
- Inventor: Ling Huang , Leslie S. Johnson
- Applicant: Ling Huang , Leslie S. Johnson
- Applicant Address: US MD Rockville
- Assignee: MacroGenics, Inc.
- Current Assignee: MacroGenics, Inc.
- Current Assignee Address: US MD Rockville
- Agency: AuerbachSchrot LLC
- Agent William C. Schrot
- International Application: PCT/US2012/038219 WO 20120516
- International Announcement: WO2012/162067 WO 20121129
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; C07K16/32
Abstract:
CD3-binding molecules capable of binding to human and non-human CD3, and in particular to such molecules that are cross-reactive with CD3 of a non-human mammal (e.g., a cynomolgus monkey) are presented. Uses of such antibodies and antigen-binding fragments in the treatment of cancer, autoimmune and/or inflammatory diseases and other conditions are presented.
Public/Granted literature
- US20140099318A1 CD3-Binding Molecules Capable of Binding to Human and Non-Human CD3 Public/Granted day:2014-04-10
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