Invention Grant
US09587029B2 Human antibodies to the glucagon receptor and methods of use thereof
有权
人胰高血糖素受体的抗体及其使用方法
- Patent Title: Human antibodies to the glucagon receptor and methods of use thereof
- Patent Title (中): 人胰高血糖素受体的抗体及其使用方法
-
Application No.: US14821652Application Date: 2015-08-07
-
Publication No.: US09587029B2Publication Date: 2017-03-07
- Inventor: Haruka Okamoto , Mark Sleeman , Joyce Harp
- Applicant: Regeneron Pharmaceuticals, Inc.
- Applicant Address: US NY Tarrytown
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: US NY Tarrytown
- Agency: Brownstein Hyatt Farber Schreck, LLP
- Agent Cara L. Crowley-Weber; Veronica Mallon
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C12N15/64 ; C12N15/70 ; A61K39/395 ; A61K45/06 ; A61K39/00

Abstract:
The present invention provides antibodies that bind to the human glucagon receptor, designated GCGR and methods of using same. According to certain embodiments of the invention, the antibodies are fully human antibodies that bind to human GCGR. The antibodies of the invention are useful for lowering blood glucose levels and blood ketone levels and are also useful for the treatment of diseases and disorders associated with one or more GCGR biological activities, including the treatment of diabetes, diabetic ketoacidosis and long-term complications associated with diabetes, or other metabolic disorders characterized in part by elevated blood glucose levels.
Public/Granted literature
- US20150337045A1 HUMAN ANTIBODIES TO THE GLUCAGON RECEPTOR Public/Granted day:2015-11-26
Information query