Invention Grant
US09587031B2 DNA encoding an anti-CD40 IgG2 antibody having amino acid mutations
有权
编码具有氨基酸突变的抗CD40 IgG2抗体的DNA
- Patent Title: DNA encoding an anti-CD40 IgG2 antibody having amino acid mutations
- Patent Title (中): 编码具有氨基酸突变的抗CD40 IgG2抗体的DNA
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Application No.: US14952419Application Date: 2015-11-25
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Publication No.: US09587031B2Publication Date: 2017-03-07
- Inventor: Aki Matsushima , Hiroshi Namisaki , Shigenori Yagi
- Applicant: KYOWA HAKKO KIRIN CO., LTD
- Applicant Address: JP Tokyo
- Assignee: KYOWA HAKKO KIRIN CO., LTD
- Current Assignee: KYOWA HAKKO KIRIN CO., LTD
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Main IPC: C12N15/13
- IPC: C12N15/13 ; C12N15/64 ; C07K16/28 ; C12R1/91 ; A61K39/00
Abstract:
The present invention can provide a monoclonal antibody which comprises a heavy chain constant region which is IgG2 wherein valine at position 234, glutamine at position 237 and proline at position 331 are at least substituted with alanine, alanine and serine, respectively (numbering is based on the EU index of Kabat et al); has an agonist activity; and binds to human CD40.
Public/Granted literature
- US20160075792A1 ANTIBODY CONTAINING IGG2 HAVING AMINO ACID MUTATION INTRODUCED THEREIN Public/Granted day:2016-03-17
Information query
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