Invention Grant
- Patent Title: Method of inducing homologous recombination of somatic cell
- Patent Title (中): 诱导体细胞同源重组的方法
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Application No.: US10540302Application Date: 2003-12-22
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Publication No.: US09587251B2Publication Date: 2017-03-07
- Inventor: Kunihiro Ohta , Hidetaka Seo , Takehiko Shibata
- Applicant: Kunihiro Ohta , Hidetaka Seo , Takehiko Shibata
- Applicant Address: JP Saitama JP Tokyo
- Assignee: Riken,Chiome Bioscience, Inc.
- Current Assignee: Riken,Chiome Bioscience, Inc.
- Current Assignee Address: JP Saitama JP Tokyo
- Agency: Finnegan, Henderson, Farabow, Garrett & Dunner, LLP
- Priority: JP2002-376555 20021226
- International Application: PCT/JP03/16496 WO 20031222
- International Announcement: WO2004/058964 WO 20040715
- Main IPC: C12N15/90
- IPC: C12N15/90
Abstract:
The present invention provides a method for obtaining diverse novel genes by inducing somatic cell homologous recombination at genetic loci in somatic cells.By controlling transcription activity of a gene that exists at a genetic locus in a eukaryotic organism cell wherein DNA homologous recombination is occurring at an arbitrary genetic locus, somatic cell homologous recombination is induced between said gene and a gene having a DNA sequence similar to said gene that exists in a region upstream of a transcription promoter, whereby it is possible to obtain diverse novel genes having a plurality of genetic information.
Public/Granted literature
- US20060099678A1 Method of inducing homologous recombination of somatic cell Public/Granted day:2006-05-11
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