Invention Grant
US09587274B2 System and method for correcting primer extension errors in nucleic acid sequence data
有权
用于校正核酸序列数据中引物延伸误差的系统和方法
- Patent Title: System and method for correcting primer extension errors in nucleic acid sequence data
- Patent Title (中): 用于校正核酸序列数据中引物延伸误差的系统和方法
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Application No.: US13608841Application Date: 2012-09-10
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Publication No.: US09587274B2Publication Date: 2017-03-07
- Inventor: Yi-Ju Chen , Keith McDade , John Simpson
- Applicant: Yi-Ju Chen , Keith McDade , John Simpson
- Applicant Address: US CT Branford
- Assignee: 454 Life Sciences Corporation
- Current Assignee: 454 Life Sciences Corporation
- Current Assignee Address: US CT Branford
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Christina K. Stock
- Main IPC: G06F19/20
- IPC: G06F19/20 ; G06F15/00 ; C12Q1/68 ; G06F19/24 ; G06F19/22

Abstract:
An embodiment of method for correcting an error associated with phasic synchrony of sequence data generated from a population of substantially identical copies of a template molecule is described that comprises (a) detecting a signal generated in response to an incorporation of one or more nucleotides in a sequencing reaction; (b) generating a value for the signal; and (c) correcting the value for the phasic synchrony error using a first parameter and a second carry forward parameter.
Public/Granted literature
- US20130054171A1 System and Method for Correcting Primer Extension Errors in Nucleic Acid Sequence Data Public/Granted day:2013-02-28
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